Hattersley AT, Beards F, Ballantyne E, et al. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Developmental processes and the induction of cardiovascular function: conceptual aspects. Developmental plasticity and human health. Weight in infancy and death from ischaemic heart disease. 2016 4.pii:E83.īarker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ. The implications of the developmental origins of health and disease on public health policy and health promotion in South Africa. Early determinants of chronic disease in developing countries. Intrauterine programming of diabetes and adiposity. Tomar AS, Tallapragada DS, Nongmaithem SS, et al.
Catch up growth in low birth weight infants: striking a healthy balance. The role of infant nutrition in the global epidemic of non-communicable disease. (CIBA Foundation Symposium 156): Chichester, UK: Whiley 1991. The Childhood Environment and Adult Disease. Developmental origins of health and disease: a lifecourse approach to the prevention of non-communicable diseases. Time for the UK to commit to tackling child obesity. Mechanisms, pathophysiology, and management of obesity. The present review considers the evidence for the developmental origins of obesity, the mechanisms involved, and the implications for public health. Although further data from experimental studies is required to support a causal link between early nutrition and future adiposity, the developmental origins hypothesis is already changing health policy and practice globally. Proposed mechanisms have included effects of early nutrition on the epigenome, hormones such as insulin, and regulation of appetite, that effect long-term risk of obesity.
For instance, optimising nutrition in pregnancy (both in terms of under-nutrition and over-nutrition) and preventing too fast infant weight gain have been shown to reduce the risk of future obesity. The concept is strongly supported by evidence from animal studies, both observational and experimental (randomised) studies in humans, and is highly relevant for population health in both low-income and high-incomes countries. This concept is particularly relevant for the development of obesity and its complications, arguably the most important public health issue of the twenty-first century worldwide. The idea that nutrition in early life (such as before conception, during pregnancy and in infancy) can influence, or programme, long-term health, known as the ‘Developmental Origins of Health and Disease Hypothesis’, has generated great scientific interest.
0 kommentar(er)
